What it is: GW-501516 is the first highly selective synthetic PPARδ agonist available. GW-501516 binds to human PPARδ. Peroxisome proliferator-activated receptor δ (PPARδ) stimulation or over-expression in adipocytes leads to increased fatty acid oxidation, improved exercise tolerance, and resistance to obesity. In obese primates, GW-501516 increases high density lipoprotein cholesterol and apolipoprotein A-1. GW-501516 is therefore a model compound for a new type of obesity therapeutic, as well as a selective pharmacological tool for understanding lipid metabolism.
FUNCTIONS: Several research studies have been conducted on rats with Cardarine (GW-501516) implementation. GW is a selective agonist, or activator, of the PPAR receptor. The binding of GW-501516 to PPAR recruits the co activator PGC-1a. The PPAR/co activator complex then up regulates the expression of proteins involved in energy expenditure.
GW-501516 has also show to increase fatty acid metabolism in skeletal muscle and protect against obesity caused from diet. Testing conducted on obese rhesus monkeys proved GW increased HDL (good cholesterol) and lowered VLDL (bad cholesterol). GW was originally intended to be created as a treatment for cholesterol problems, which it has shown to possess a high rate of efficacy in doing.
Uses and Abilities: GW-501516 possesses many strong attributes and abilities but is known for two major strengths.
The endurance benefits that can be obtained with GW-501516 research are unmatched. There is a strong reason that it has been banned in many professional sport settings, most notably, the Olympics, NCAA and with professional cyclists. GW-501516 can drastically improve endurance over extended periods of time buy expanding the VO2 max, allowing for continuous improvements in aerobic capacity. This allows for research subjects to reach potential that would otherwise be unattainable. This SARM PPAR modulator allows one to overcome plateaus and reach peak level.
GW-501516 was originally designed to treat cholesterol and this is a characteristic that should never be forgotten, yet in many circumstances, it is. Although this is an extremely strong characteristic, this is not one of the top two major strengths it is known for. This characteristic is that of fat loss. GW is extremely desirable because it has the ability to shed fat rapidly while staying in a non-catabolic state. GW gives one the ability to drop fat at a far higher rate than generally possibly, yet in an extremely safe facet.
***RESEARCH USE ONLY***
*The information herein is for educational and informational purposes only. THIS PRODUCT IS FOR RESEARCH USE ONLY. For use in animal studies, all research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
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