Ghrelin is an endogenous ligand for the growth hormone (GH) secretagogue receptor (GHSR). Ibutamoren (MK-677) is an orally-active, non-peptidic agonist of GHSR and, as a result, is a GH secretagogue. It elevates GH in dogs after oral doses as low as 0.125 mg/kg, without significantly changing plasma levels of aldosterone, luteinizing hormone, thyroxine, or prolactin.
CLINICAL FINDINGS OF MK-677:
Increases in fat free mass
Enhanced sleep quality
Lowering of bad cholesterol (LDL)
Significant improvements in nitrogen balance
Reversal of diet-induced nitrogen wasting
Increase in basal metabolic rate
Mild lower extremity edema and muscle pain.
Clinical studies conducted had dosing between 5-25 mg per day, with 25 mg being the most common and effective dose. MK-677 has a 24 hour half-life and showed to be best tolerated when fed to rats each morning on an empty stomach.
***RESEARCH USE ONLY***
*The information herein is for educational and informational purposes only. THIS PRODUCT IS FOR RESEARCH USE ONLY. For use in animal studies, all research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
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